levamisole usage as an adjuvant to hepatitis b vaccine in hemodialysis patients, yes or no?
نویسندگان
چکیده
background hepatitis b virus (hbv) infection is much more common in hemodialysis patients than the general population. these patients have an impaired immune response to hbv vaccination; to that end there are certain studies that have evaluated levamisole as an immunomodulator agent improving hbv vaccination response rate in hemodialysis patients. objectives in the current review, we have assembled all of the results to determine whether lavamisole is of value as an adjuvant to hbv vaccination in hemodialysis patients. materials and methods science direct (elsevier), proquest, springer, md consult, bmj journals, pubmed and wiley were searched for levamisole application to hbv vaccination in hemodialysis patients. all studies revealed a seroconversion response level between levamisole plus hbv vaccine versus hbv vaccine alone. results from 10 relevant studies, 5 studies fulfilled our inclusion criteria. three of them suggested the significant benefit of adding levamisole to the hbv vaccine to increase augment seroprotection level in hemodialysis patients. another study reported a decrease in seroprotection level and another study showed no significant difference caused by levamisole administration. conclusions due to the limited number of studies evaluated, it is challenging to perform a definite decision about routinely administering levamisole in addition to the hbv vaccine for all hemodialysis patients. however, it does seem reasonable to recommend administration of levamisole for impaired immune response patients.
منابع مشابه
Levamisole Usage as an Adjuvant to Hepatitis B Vaccine in Hemodialysis Patients, Yes or No?
BACKGROUND Hepatitis B virus (HBV) infection is much more common in hemodialysis patients than the general population. These patients have an impaired immune response to HBV vaccination; to that end there are certain studies that have evaluated levamisole as an immunomodulator agent improving HBV vaccination response rate in hemodialysis patients. OBJECTIVES In the current review, we have ass...
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background human immunodeficiency virus (hiv) infected patients are also frequently exposed to the hepatitis b virus (hbv), due to the common routes of transmission, therefore, prevention of hepatitis b results in decreased complications of the disease. objectives since the immune response of hiv patients to hepatitis b vaccination is less robust than that found in healthy individuals, this stu...
متن کاملLevamisole as an adjuvant to hepatitis B vaccination in patients with chronic kidney disease
© 2015 The Authors; Tabriz University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Levamisole as an adjuvant to hepatitis B vaccination in patients w...
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BACKGROUND Human immunodeficiency virus (HIV) infected patients are also frequently exposed to the hepatitis B virus (HBV), due to the common routes of transmission, therefore, prevention of hepatitis B results in decreased complications of the disease. OBJECTIVES Since the immune response of HIV patients to hepatitis B vaccination is less robust than that found in healthy individuals, this s...
متن کاملVariability in Response to Hepatitis B Vaccine in Hemodialysis Patients
BACKGROUND Hemodialysis patients are exposed to blood and blood products more than the general population and are also at higher risk for hepatitis B (HB) contamination. For these reasons, it is highly recommended that this patient population gets the HB vaccine. The efficacy of the vaccine is measured by measuring titers of antibody in the serum of the patient. A minimum titer of 10 mIU/mL is ...
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عنوان ژورنال:
nephro-urology monthlyجلد ۵، شماره ۱، صفحات ۶۷۳-۶۷۸
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